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Prognostic significance of DNA cytometry for adjuvant therapy response in pancreatic cancer
Author(s) -
Klein Fritz,
Bahra Marcus,
Schirmeier Anja,
AlAbadi Hussein,
Pratschke Johann,
Pelzer Uwe,
Oettle Helmut,
Striefler Jana,
Riess Hanno,
Sinn Marianne
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23951
Subject(s) - medicine , grading (engineering) , oncology , adjuvant therapy , population , adenocarcinoma , pancreatic cancer , gastroenterology , pathology , cancer , biology , ecology , environmental health
Background and Objectives The continuous progress in treatment options for pancreatic adenocarcinoma has lead to a re‐evaluation of prognostic markers. In this study the prognostic relevance of DNA Index and classical histopathological parameters with regard to disease‐free (DFS) and overall survival (OS) was analyzed within the CONKO‐001 patient population. Methods One hundred forty three fresh‐frozen paraffin‐embedded tissue samples of the resected tumor specimen of the CONKO‐001 patient population were available for DNA index analysis to evaluate its impact on patient outcome. Results Median DFS (7.3 vs. 14.3 months; P = 0.004) and median OS (16.6 vs. 29.2 months; P = 0.011) were significantly decreased in patients with a high DNA index (>1.4). Multivariate analysis revealed both DNA index (DFS: P = 0.002; OS: P = 0.019) and tumor grading (DFS: P = 0.004; OS: P = 0.004) as individual prognostic markers for DFS and OS. The following prognostic subgroups were identified: good (low DNA Index + G1/2 tumor grading), intermediate (low DNA Index + G3 tumor grading or high DNA Index + G1/2 tumor grading), poor (high DNA Index + G3 tumor grading). Conclusion The DNA index/tumor grading constellation may serve as a helpful guide for personalized treatment recommendations for adjuvant therapy of patients with pancreatic adenocarcinoma. J. Surg. Oncol. 2015 111:66–71 . © 2015 Wiley Periodicals, Inc.