Premium
Prognostic value of lymph node density in high‐grade salivary gland cancers
Author(s) -
Hong Hye Ran,
Roh JongLyel,
Cho KyungJa,
Choi SeungHo,
Nam Soon Yuhl,
Kim Sang Yoon
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23874
Subject(s) - medicine , perineural invasion , univariate analysis , lymphovascular invasion , lymph node , salivary duct carcinoma , carcinoma ex pleomorphic adenoma , neck dissection , stage (stratigraphy) , salivary gland , oncology , salivary gland cancer , proportional hazards model , pathology , carcinoma , lymph , metastasis , multivariate analysis , cancer , pleomorphic adenoma , paleontology , biology
Background To investigate the role of lymph node density (LND) as an independent prognostic factor in high‐grade salivary gland cancers. Methods All 87 patients with high‐grade salivary gland cancers underwent curative surgery combined with neck dissection and most of them received postoperative radiotherapy or chemoradiotherapy. LND was calculated as the ratio of positive lymph nodes to total lymph nodes harvested. Clinicopathologic variables associated with cancer‐specific survival (CSS) and overall survival (OS) were identified by univariate and multivariate analyses using the Cox‐proportional hazards model. Results Salivary duct carcinoma was the most common tumor (54%), followed by carcinoma ex pleomorphic adenoma (22%), and others. The 5‐year CSS and OS were 50.9% and 49.6%, respectively, during a median follow‐up of 61 months. In univariate analysis, tumor site, pathologic nodal stage, overall tumor‐node‐metastasis (TNM) stage, primary tumor size >3 cm, lymphovascular invasion, perineural invasion, extranodal extension, number of metastatic lymph nodes, and LND >4.0 were significant prognostic factors for CSS and OS ( P < 0.05 each). Tumor site, perineural invasion, and LND were independent prognostic factors for both CSS and OS in multivariate analysis ( P < 0.01). Conclusion Our findings support the prognostic value of LND for high‐grade salivary gland cancers. J. Surg. Oncol. 2015 111:784–789 . © 2015 Wiley Periodicals, Inc.