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Etiologic, environmental and inherited risk factors in sarcomas
Author(s) -
Thomas David M.,
Ballinger Mandy L.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23809
Subject(s) - medicine , sarcoma , etiology , li–fraumeni syndrome , genetic predisposition , population , carcinogen , cancer , oncology , pathology , environmental health , genetics , germline mutation , mutation , disease , gene , biology
Sarcomas are a rare group of mesenchymal tumors affecting a younger population. The etiology remains unknown in most cases. Environmental factors that increase sarcoma risk include radiation exposure and chemical carcinogens. Several familial cancer syndromes confer sarcoma predisposition, such as the Li‐Fraumeni Syndrome (LFS). In this increasingly genomic focussed era of medicine, it will be clinically important to understand the genetic basis of sarcoma risk. J. Surg. Oncol. 2015 111:490–495 . © 2014 Wiley Periodicals, Inc.