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Molecular markers for colon diagnosis, prognosis and targeted therapy
Author(s) -
Herzig Daniel O.,
Tsikitis Vassiliki L.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23806
Subject(s) - medicine , colorectal cancer , adenocarcinoma , oncology , colorectal adenocarcinoma , carcinogenesis , cancer , cancer research , gastroenterology
Colorectal adenocarcinoma (CRC), the second leading cancer‐related death in the United States, remains a global public health issue. Sporadic CRC is considered the result of sequential mucosal changes from normal colonic mucosa to adenocarcinoma. Efforts in understanding the molecular pathways leading to CRC tumorigenesis may lead to identifying novel, individually tailored therapeutic targets for patients. In this review, we focus on well‐published prognostic and predictive markers in CRC and examine their role in clinical practice. J. Surg. Oncol. 2015 111:96–102 . © 2014 Wiley Periodicals, Inc.