Premium
Does preoperative biliary drainage compromise the long‐term survival of patients with pancreatic head carcinoma?
Author(s) -
Murakami Yoshiaki,
Uemura Kenichiro,
Hashimoto Yasushi,
Kondo Naru,
Nakagawa Naoya,
Sasaki Hayato,
Hatano Naoto,
Kohmo Toshiaki,
Sueda Taijiro
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23797
Subject(s) - medicine , biliary drainage , carcinoma , surgery , pancreatic head , univariate analysis , survival rate , multivariate analysis , gastroenterology , medical record , survival analysis , resection
Background and Objectives The aim of this study was to determine the impact of preoperative biliary drainage (PBD) on long‐term survival in patients with pancreatic head carcinoma after surgical resection. Methods Medical records of 160 patients with pancreatic head carcinoma who underwent surgical resection were reviewed retrospectively. Clinicopathological parameters including long‐term survival were compared between patients who did and did not undergo PBD. Results Overall survival of patients who underwent PBD (n = 93) was significantly worse than that of patients who did not (n = 67) by univariate analysis ( P = 0.030). However, multivariate analysis revealed that PBD was not an independent prognostic factor for overall survival ( P = 0.227). Patients who underwent percutaneous transhepatic biliary drainage (PTBD) had significantly worse survival than patients who underwent endoscopic retrograde biliary drainage (ERBD, P = 0.038) and patients who did not undergo PBD ( P = 0.001). The rate of peritoneal recurrence in patients who underwent PTBD was significantly higher than that of patients who underwent ERBD ( P = 0.033) or patients who did not undergo PBD ( P = 0.034). Conclusions PBD may not affect the long‐term survival of patients with pancreatic head carcinoma if ERBD is used. J. Surg. Oncol. 2015 111:270–276 . © 2014 Wiley Periodicals, Inc.