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A study of the impact of the 21‐gene breast cancer assay on the use of adjuvant chemotherapy in women with breast cancer in a Mexican public hospital
Author(s) -
Bargallo Juan Enrique,
Lara Fernando,
ShawDulin Robin,
PerezSánchez Victor,
VillarrealGarza Cynthia,
MaldonadoMartinez Hector,
MoharBetancourt Alejandro,
Yoshizawa Carl,
Burke Emily,
Decker Timothy,
Chao Calvin
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23794
Subject(s) - medicine , breast cancer , chemotherapy , oncology , stage (stratigraphy) , adjuvant chemotherapy , adjuvant , receipt , cancer , adjuvant therapy , gynecology , paleontology , world wide web , computer science , biology
Background The majority of breast cancer patients in Mexico are treated through the public health system and >80% receive adjuvant chemotherapy. The aim of this prospective study was to characterize the impact of the Oncotype DX assay on adjuvant therapy decision making and the confidence in those decisions amongst public sector physicians in Mexico. Methods Ninety‐eight consecutive patients with ER+, HER2−, stage I–IIIa, N0/N1‐3 node‐positive breast cancer from the Instituto Nacional de Cancerología were eligible for the study. The primary endpoint was the overall change in treatment recommendations after receiving the assay results. Results Of 96 patients, 48% received a chemohormonal therapy recommendation prior to testing. Following receipt of results, treatment decisions changed for 31/96 (32%) patients, including 17/62 (27%) node‐negative patients and 14/34 (41%) node‐positive patients. The proportion of patients with a chemotherapy‐based recommendation decreased from 48% pre‐ to 34% post‐assay ( P = 0.024). 92% of physicians agreed that they were more confident in their treatment recommendation after ordering the assay. Conclusions These results suggest that use of the 21‐gene assay in the Mexican public health system has a meaningful impact on adjuvant treatment recommendations that may reduce the overall use of chemotherapy. J. Surg. Oncol. 2015;111:203–207 . © 2014 The Authors. Journal of Surgical Oncology published by Wiley Periodicals, Inc.