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Outcomes after curative hepatectomy in patients with non‐B non‐C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non‐cirrhotic liver
Author(s) -
Kim Jong Man,
Kwon Choon Hyuck David,
Joh JaeWon,
Park Jae Berm,
Lee Joon Hyeok,
Kim Sung Joo,
Paik Seung Woon,
Park Cheol Keun,
Yoo Byung Chul
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23772
Subject(s) - hepatocellular carcinoma , medicine , gastroenterology , hepatectomy , hepatitis b virus , hepatitis b , hbsag , liver function , virus , surgery , immunology , resection
Backgrounds and Objective There is controversy regarding liver function of non‐B, non‐C hepatocellular carcinoma (NBNC‐HCC) patients, the biological behavior of their tumors, and the outcome after surgical treatment. The aims of the present study were to compare clinicopathologic data and long‐term clinical outcomes between NBNC‐HCC patients and hepatitis B virus HCC (HBV‐HCC) patients from non‐cirrhotic liver after curative hepatectomy. Methods Data for HBV‐HCC patients (n = 360) and NBNC‐HCC patients (n = 103) were retrospectively reviewed. Results The median age of patients in the NBNC group was significantly higher than that of the HBV group (63 years vs. 53 years, P < 0.001). Tumor size in the NBNC group was greater than that in the HBV group (5.1 cm vs. 3.8 cm, P < 0.001). Regarding liver histology, the grade of lobular activity, periportal activity, and fibrosis in the HBV group was higher than in the NBNC group ( P < 0.001, P < 0.001, and P < 0.001, respectively). There were no statistically significant differences in disease‐free survival and overall survival between the two groups ( P = 0.257 and P = 0.579, respectively). Multivariate analysis showed that increased tumor size, microvascular invasion, and intrahepatic metastasis were associated with tumor recurrence after curative liver resection. Conclusion For patients with non‐cirrhotic liver, clinical outcomes for NBNC‐HCC were comparable to those for HBV‐HCC after curative hepatectomy. J. Surg. Oncol. 2014; 110:976–981 . © 2014 Wiley Periodicals, Inc.