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Prognostic impact of tumoral and/or peri‐tumoral stromal SPARC expressions after surgery in patients with biliary tract cancer
Author(s) -
Nakashima Shinsuke,
Kobayashi Shogo,
Sakai Daisuke,
Tomokuni Akira,
Tomimaru Yoshito,
Hama Naoki,
Wada Hiroshi,
Kawamoto Koichi,
Marubashi Shigeru,
Eguchi Hidetoshi,
Matsuura Nariaki,
Doki Yuichiro,
Mori Masaki,
Nagano Hiroaki
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23767
Subject(s) - stromal cell , medicine , osteonectin , immunohistochemistry , matricellular protein , hazard ratio , cancer , pathology , lymphovascular invasion , metastasis , cancer research , oncology , extracellular matrix , biology , confidence interval , biochemistry , alkaline phosphatase , osteocalcin , enzyme , microbiology and biotechnology
Background and Objective SPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that modulates interactions between tumoral cells and the peri‐tumoralstroma. SPARC induces proliferation and invasion in vitro, and is a poor prognostic factor in several gastrointestinal cancers. Herein, we evaluated the prognostic value of tumoral and stromal SPARC expression in patients with biliary tract cancer (BTC) after surgery. Methods We examined immunohistochemical patterns of SPARC expression in 110 resected BTC specimens and evaluated the prognostic value using prospectively collected data. Results SPARC was expressed in tumoral cells in 46 samples (42%) and inperi‐tumoralstromain 65 samples (59%). Tumoral SPARC expression was not related to major patient characteristics. Stromal SPARC expression was related to lymph node metastasis, stage, margin status, and tumor location. Overall survival at 5 years after surgery was 34.2%. Stromal SPARC ( P < 0.001) and tumoral SPARC ( P = 0.048) were associated with poor prognosis. Multivariate analysis revealed invasion into lymphatic system, residual tumor, and stromal SPARC as independent prognostic factors. The hazard ratio for patients with positive stromal SPARC was 3.20 ( P < 0.001). Conclusion SPARC expression inperi‐tumoralstroma predicts a poor prognosis for patients with BTC after surgery. J. Surg. Oncol. 2014; 110:1016–1022 . © 2014 Wiley Periodicals, Inc.