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Hereditary cancer syndromes with high risk of endometrial and ovarian cancer: Surgical options for personalized care
Author(s) -
McCann Georgia A.,
Eisenhauer Eric L.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23743
Subject(s) - medicine , lynch syndrome , endometrial cancer , ovarian cancer , prophylactic surgery , prophylactic mastectomy , hysterectomy , gynecology , oophorectomy , breast cancer , mastectomy , cancer , obstetrics , oncology , surgery , dna mismatch repair , colorectal cancer
Cancer genomics has increased our recognition of specific hereditary cancer mutations. Hereditary breast and ovarian cancer (HBOC) syndrome and Lynch syndrome are two such entities in which women carrying specific mutations may be at high risk for developing breast, ovarian, and/or endometrial cancers. Risk reducing surgery such as prophylactic mastectomy, oophorectomy, and/or hysterectomy may allow women to decrease these risks after completing childbearing. Background, indications, and consequences of these procedures are reviewed. J. Surg. Oncol. 2015 111:118–124 . © 2014 Wiley Periodicals, Inc.