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Cowden syndrome: Recognizing and managing a not‐so‐rare hereditary cancer syndrome
Author(s) -
Mester Jessica,
Eng Charis
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23735
Subject(s) - medicine , cowden syndrome , dermatology , cancer , mutation , germline mutation , genetics , gene , biology
Cowden syndrome (CS) is an autosomal dominant hereditary cancer syndrome causing increased risk for breast, thyroid, renal, uterine, and other cancers as well as benign neoplasias and neurodevelopmental concerns. Timely diagnosis of affected patients is key, as early recognition allows for high‐risk screening and other preventative measures prior to a patient enduring multiple cancer diagnoses. This review will highlight the cardinal features of CS and management recommendations for affected patients. J. Surg. Oncol. 2015 111:125–130 . © 2014 Wiley Periodicals, Inc.