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Hereditary colorectal cancer syndromes and genetic testing
Author(s) -
Macaron Carole,
Leach Brandie H.,
Burke Carol A.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23706
Subject(s) - medicine , colorectal cancer , cancer , genetic testing , genetic counseling , genetic syndromes , lynch syndrome , hereditary cancer , oncology , pediatrics , genetics , dna mismatch repair , breast cancer , biology
Colorectal cancer (CRC) is a leading cause of cancer and cancer deaths in the Western world. Approximately 5–10% of CRC are hereditary, due to a defined genetic cause. Individuals and families affected with a hereditary CRC syndrome exhibit benign and malignant extra‐intestinal tumors, require aggressive cancer screening and benefit from management by a multi‐disciplinary team of professionals. The clinical manifestations, genetic causes and current management of patients with hereditary colon cancer syndrome is provided. J. Surg. Oncol. 2015 111:103–111 . © 2014 Wiley Periodicals, Inc.