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Clinical values of 18 F‐FDG PET/CT in oral cavity cancer with dental artifacts on CT or MRI
Author(s) -
Hong Hye Ran,
Jin Soyoung,
Koo Hyun Jung,
Roh JongLyel,
Kim Jae Seung,
Cho KyungJa,
Choi SeungHo,
Nam Soon Yuhl,
Kim Sang Yoon
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23691
Subject(s) - medicine , nuclear medicine , mcnemar's test , radiology , intraclass correlation , magnetic resonance imaging , oral cavity , clinical psychology , statistics , mathematics , orthodontics , psychometrics
Level of Evidence: 2a Background and Objectives: To investigate the role of 18 F‐FDG PET/CT in tumor staging, extent, and volume measurements in oral cavity squamous cell carcinoma (OSCC) patients with/without dental artifacts on CT or MRI. Methods: This study was conducted in 63 consecutive patients with OSCC who received initial workups including 18 F‐FDG PET/CT and MRI. The results of the imaging modalities were compared to those of pathology, using McNemar's test and the paired t ‐test. Results: Thirty‐seven patients (59%) had dental or metallic artifacts obscuring primary tumors. 18 F‐FDG PET/CT scanning was superior to MRI in tumor staging (weighted κ = 0.870 vs. 0.518, P = 0.004) in patients with dental artifacts. In addition, 18 F‐FDG PET/CT scans were more specific than MRI in detecting sublingual gland ( P = 0.014) and mouth floor ( P = 0.011) involvement. In patients with dental artifacts, there was a significant discrepancy between primary tumor volume (PTV) measured by pathology and MRI ( P = 0.018), but not between PTV measured from pathology and 18 F‐FDG PET/CT at SUV2.5 ( P = 0.245), which showed the highest intraclass correlation coefficient value (0.860). Conclusion: 18 F‐FDG PET/CT scans provide accurate tumor staging and volume measurements in OSCC patients with CR/MRI dental artifacts, leading to improved preoperative planning. Level of Evidence: 2b CONDENSED ABSTRACT This study evaluated the clinical value of 18 F‐FDG PET/CT in 63 patients with oral cavity cancers. In 37 (59%) patients with dental artifacts on CT/MRI, 18 F‐FDG PET/CT showed superior results compared to MRI in tumor staging and represented the highest intraclass correlation coefficient value to tumor volume determined by pathology. J. Surg. Oncol. 2014 110:696–701 . © 2014 Wiley Periodicals, Inc.