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Examination of national lymph node evaluation practices for adult extremity soft tissue sarcoma
Author(s) -
Sherman Karen L.,
Kinnier Christine V.,
Farina Domenico A.,
Wayne Jeffrey D.,
Laskin William B.,
Agulnik Mark,
Attar Samer,
Hayes John P.,
Peabody Terrance,
Bilimoria Karl Y.
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23687
Subject(s) - medicine , rhabdomyosarcoma , soft tissue sarcoma , sarcoma , nodal , clear cell sarcoma , epithelioid sarcoma , lymph node , synovial sarcoma , angiosarcoma , metastasis , cancer , pathology , oncology , radiology
Background and Objectives Lymph node evaluation recommendations for extremity soft tissue sarcoma (ESTS) are absent from national guidelines. Our objectives were (1) to assess rates and predictors of nodal evaluation, and (2) to assess rates and predictors of nodal metastases. Methods ESTS patients from the National Cancer Data Base (2000–2009) were assessed, and regression models were used to identify factors associated with nodal evaluation and metastases. Results Of 27,536 ESTS patients, 1,924 (7%) underwent nodal evaluation, and of these, 290 (15%) had nodal metastases. Nodal evaluation was most frequently performed for rhabdomyosarcoma (15.6%), angiosarcoma (10.0%), clear cell sarcoma (39.3%), epithelioid sarcoma (28.1%), and synovial sarcoma (9.3%). On multivariable analysis, factors associated with nodal evaluation included histologic subtype, tumor size, and grade. Nodal metastasis rates were highest among patients with rhabdomyosarcoma (32.1%), angiosarcoma (24.1%), clear cell sarcoma (27.7%), and epithelioid sarcoma (31.8%). On multivariable analysis, factors associated with nodal metastases included histologic subtype, tumor size, and grade. Conclusions Nodal evaluation rates are highest among certain expected subtypes but are generally low. However, nodal metastasis rates for many histologic subtypes in patients selected for lymph node evaluation may be higher than previously reported. Multi‐institutional studies should address nodal evaluation for ESTS. J. Surg. Oncol. 2014 110:682–688 . © 2014 Wiley Periodicals, Inc.