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Hepatocellular carcinoma: A comprehensive overview of surgical therapy
Author(s) -
Fonseca Annabelle L.,
Cha Charles H.
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23673
Subject(s) - medicine , hepatocellular carcinoma , liver transplantation , milan criteria , modalities , resection , treatment modality , transplantation , surgery , surgical resection , hepatectomy , general surgery , social science , sociology
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, with a rising incidence in the United States. The increase in medical and locally ablative therapies have improved prognosis, however surgery, either liver resection or transplantation, remains the mainstay of therapy. An increased understanding of liver anatomy, improved imaging modalities and refinements of surgical technique have all led to improved outcomes after surgery. Both resection and transplantation may be used in a complementary manner. Resection remains the treatment of choice for HCC when feasible. Liver transplantation, which removes both the tumor and the underlying diseased liver offers excellent outcomes in patients that meet the Milan criteria. While both these modalities have relatively well defined roles, the treatment of these patients must be tailored individually, using a multidisciplinary approach, to maximize survival, quality of life and allocation of scarce organs. J. Surg. Oncol. 2014 110:712–719 . © 2014 Wiley Periodicals, Inc.