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The preoperative neutrophil–lymphocyte ratio predicts recurrence and survival among patients undergoing R0 resections of adenocarcinomas of the esophagogastric junction
Author(s) -
Yuan Dawei,
Zhu Kun,
Li Kang,
Yan Rong,
Jia Yong,
Dang Chengxue
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23651
Subject(s) - medicine , neutrophil to lymphocyte ratio , hazard ratio , gastroenterology , univariate analysis , proportional hazards model , histopathology , stage (stratigraphy) , lymphocyte , histology , multivariate analysis , adenocarcinoma , cancer , surgery , confidence interval , pathology , paleontology , biology
Background and Objectives Elevated preoperative neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) predict survival rates among patients with several types of cancer. The current study sought to clarify whether NLR and PLR are clinically useful independent prognostic indicators of adenocarcinomas of the esophagogastric junction (AEG) among patients undergoing curative resections (i.e., R0 resections). Methods A total of 327 patients who underwent R0 resections for AEG were enrolled in the study. Data concerning demographic parameters, laboratory analyses, histopathology, and survival time were collected and analyzed. Results A total of 123 patients (37.6%) had elevated preoperative NLR (≥5). The median follow‐up duration was 24.7 months (range = 2–39 months). NLR was significantly related to histology ( P = 0.035), pTNM stage ( P < 0.0001) and tumor recurrence ( P = 0.022). Univariate analyses revealed that NLR were significantly associated with disease‐free survival (DFS) and overall survival (OS; both P < 0.0001). Multivariable analyses revealed that elevated NLR independently predicted poorer DFS (hazard ratio [HR] = 2.551, P < 0.0001) and OS (HR = 2.743, P < 0.0001). However, PLR did not significantly predict DFS or OS. Conclusion The present study indicates that elevated preoperative NLR (≥5) is a useful marker of tumor recurrence and independently predicts poorer disease‐free and overall survival among patients with AEG undergoing R0 resections. J. Surg. Oncol. 2014 110:333–340 . © 2014 Wiley Periodicals, Inc.