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Clinical outcome of subcentimeter non‐small cell lung cancer after surgical resection: Single institution experience of 105 patients
Author(s) -
Jiang Wei,
Pang Xuguang,
Xi Junjie,
Chen Xiaoke,
Wang Qun,
Qian Cheng,
Fan Hong
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23647
Subject(s) - medicine , wedge resection , lung cancer , exact test , multivariate analysis , proportional hazards model , continuous variable , pneumonectomy , survival analysis , dissection (medical) , retrospective cohort study , surgery , radiology , resection
Background The detection of subcentimeter lung cancers has significantly improved with advances in computed tomography and the emergence of screening protocols. We reviewed the clinicopathological features and surgical outcomes of patients with subcentimeter non‐small cell lung cancer (NSCLC) in our institution. Methods A total of 105 patients who underwent lobectomy or sublobar resection for subcentimeter NSCLCs were retrospectively reviewed. Clinicopathological characteristics and survival were analyzed statistically using Student's t ‐test for continuous variables, Fisher's exact for categorical variables and Cox regression for multivariable analysis. Results A total of 105 patients (35 male, 70 female; mean age 61.4, range 38–77 years) were analyzed. Patients underwent lobectomy (n = 71), segmentectomy (n = 19), or wedge resection (n = 15). The overall 5‐year survival was 91.3%. No significant differences were observed in overall and recurrence‐free survival after segmentectomy or lobectomy; patients undergoing wedge resection had shorter survival compared to those who underwent lobectomy. Elevated preoperative serum CEA levels and positive nodal status correlated with poorer survival, and were identified as independent prognostic factors in multivariate analysis. Conclusion Systematic nodal dissection is recommended for patients with subcentimeter NSCLC. Segmentectomy offers comparable oncologic results to lobectomy. Elevated preoperative serum CEA level implies shorter survival for patients with these tiny tumors. J. Surg. Oncol. 2014 110:233–238 . © 2014 Wiley Periodicals, Inc.