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Treatment and survival of patients with occult breast cancer with axillary lymph node metastasis: A nationwide retrospective study
Author(s) -
Sohn Guiyun,
Son Byung Ho,
Lee Soo Jung,
Kang Eun Young,
Jung Sung Hoo,
Cho SeHeon,
Baek Seunghee,
Lee Yu Ra,
Kim Hee Jung,
Ko Beom Suk,
Lee Jong Won,
Ahn SeiHyun
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23644
Subject(s) - medicine , axillary lymph node dissection , breast cancer , hazard ratio , retrospective cohort study , mastectomy , occult , univariate analysis , oncology , confidence interval , proportional hazards model , cancer , surgery , pathology , multivariate analysis , sentinel lymph node , alternative medicine
Background and Objectives Occult breast cancer (OBC) accounts for 0.3–1.0% of all breast cancers and is a rare presentation of the disease. The present retrospective study examined the overall survival and prognostic factors associated with OBC in Korea. Method The study included 142 OBC patients identified from the Korean Breast Cancer Society cancer registry from January 1990 to December2009. All patients had pathologically positive axillary lymph nodes (N1–N3) and pathologically and radiologically negative in‐breast lesions (T0/Tx) based on a retrospective review of the database. Results No statistically significant differences in overall survival were observed between patients undergoing axillary lymph node dissection (ALND) only (80.8%), breast conserving surgery (BCS) with ALND (98.0%), and mastectomy with ALND (92.5%) with P ‐value of 0.061. Nodal status was a significant prognostic factor ( P = 0.004) on univariate analysis. When compared with T1 patients group, T0/TxN1 patients showed better survival than T1N1 patients (hazard ratio [HR] 0.253; 95% confidence interval, 0.104–0.618; P = 0.003), but T0/TxN2, T0/TxN3 patients showed similar survival to T1N2, T1N3 patients. Conclusions OBC patients treated with ALND only showed comparable outcomes to those undergoing ALND combined with BCS or mastectomy. Nodal status may be an independent predictor of poor outcome in OBC patients. J. Surg. Oncol. 2014 110:270–274 . © 2014 Wiley Periodicals, Inc.