Premium
Genetic variations are associated with lymph node metastasis in colorectal cancer patients
Author(s) -
Lan YuanTzu,
Yang ShungHaur,
Lin JenKou,
Lin ChunChi,
Wang HuannSheng,
Chen WeiShone,
Lin TzuChen,
Jiang JengKai,
Chang ShihChing
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23613
Subject(s) - colorectal cancer , metastasis , medicine , single nucleotide polymorphism , genotype , oncology , allele , case control study , carcinogenesis , cancer , biology , genetics , gene
Background and Objectives Regional lymph nodes (LNs) are believed to be a first‐line barrier against tumor metastasis. However, it remains unclear whether underlying genetic factors exist and affect LN metastasis risk. We therefore evaluated inherited risk variants using single nucleotide polymorphisms (SNPs) in pathological T3 colorectal cancer patients in the absence or presence of LN metastasis. Methods The study population comprised 629 retrospectively collected colorectal cancer samples between 2000 and 2009 in a single hospital, including 273 patients with LN metastasis and 355 control subjects without LN metastasis. We analyzed 87 SNPs in genes that are associated with susceptibility to carcinogenesis or metastasis in colorectal or other cancers. Results Only 11 SNPs were found to have significant genotype distribution differences between the cases and controls. The average number of risk alleles carried by patients with LN metastasis was 7 (6.6 ± 1.4; range 2–10), which was significantly higher than the 6 risk alleles that were carried on average by patients without LN metastasis (6.0 ± 1.6; range 0–10; P < 0.001). Conclusions Certain SNPs can increase genetic susceptibility to LN metastasis. As the number of risk alleles increases, the risk of LN metastasis also increases, although the difference is subtle. J. Surg. Oncol. 2014 110:307–312 . © 2014 Wiley Periodicals, Inc.