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The importance of systemic therapy in minimizing local recurrence after breast‐conserving surgery: The NSABP experience
Author(s) -
Mamounas Eleftherios P.,
Tang Gong,
Liu Qing
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23609
Subject(s) - medicine , lumpectomy , systemic therapy , breast cancer , adjuvant , surgery , mastectomy , adjuvant therapy , stage (stratigraphy) , oncology , cancer , chemotherapy , paleontology , biology
Adjuvant systemic therapy significantly reduces rates of distant recurrence and death. The effect of systemic therapy is not limited to reducing distant recurrences but also extends to reducing loco‐regional recurrences, and rates of loco‐regional recurrence have steadily declined over the past 25 years. This review focuses on the effect of adjuvant systemic therapy on rates of ipsilateral breast tumor recurrence following lumpectomy plus breast irradiation in several pivotal NSABP trials in early‐stage breast cancer. J. Surg. Oncol. 2014 110:45–50 . © 2014 Wiley Periodicals, Inc.