Premium
Early experience with ultrasound features after intrabeam intraoperative radiation for early stage breast cancer
Author(s) -
Goble Rachel N.,
Drukteinis Jennifer S.,
Lee M. Catherine,
Khakpour Nazanin,
Kiluk John V.,
Laronga Christine
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23581
Subject(s) - medicine , seroma , lumpectomy , breast cancer , intraoperative radiation therapy , breast conserving surgery , mcnemar's test , stage (stratigraphy) , radiation therapy , radiology , surgery , cancer , mastectomy , complication , paleontology , statistics , mathematics , biology
Background Intraoperative radiation therapy (IORT) is an emerging option for partial breast radiotherapy in select women with early stage breast cancer. We assessed short‐term clinical and sonographic findings after breast conservation (BCT) and IORT. Methods An IRB‐approved, single institution retrospective chart review was conducted of patients (pts) treated with BCT/IORT from 1/2011 to 6/2012. Follow‐up clinical breast exams and ultrasounds (US) obtained 6 and 12 months after BCT/IORT were retrospectively reviewed by a single breast radiologist (JD) for sonographic findings. P values were calculated using McNemar's test, Wilcoxon Rank Sum Test, and Chi‐square. Results Seventy‐one pts underwent BCT/IORT and 38 pts had an US. All 38 pts had a seroma, 10/38 (26%) pts were symptomatic. Eighteen pts had deep tissue closure (DTC) of the lumpectomy cavity with 5/18 (28%) DTC pts being symptomatic at follow‐up versus 5/33 (15%) without DTC ( P = 0.296). At 6 months, DTC resulted in smaller seroma cavity volumes compared to those without DTC ( P = 0.03). Conclusion Presence of a seroma is commonplace post BCT/IORT; symptomatic seromas are uncommon. DTC generated smaller seromas. Longer follow‐up with serial US performed in all BCT/IORT pts could be considered to document natural progression/regression of symptoms and seromas. J. Surg. Oncol. 2014 109:751–755 . © 2014 Wiley Periodicals, Inc.