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Treatment strategy of rectal gastrointestinal stromal tumor (GIST)
Author(s) -
Liu Heli,
Yan Zhongshu,
Liao Guoqing,
Yin Hongling
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23562
Subject(s) - medicine , gist , rectum , hazard ratio , stromal tumor , imatinib , retrospective cohort study , surgery , resection margin , stromal cell , surgical margin , radiology , oncology , resection , confidence interval , myeloid leukemia
Background Rectal gastrointestinal stromal tumor (GIST) is a rare entity. A retrospective analysis of outcomes from a single institution to identify treatment strategies associated with improved outcomes. Methods Records of patients with GIST of the rectum were retrospectively reviewed. Patient and tumor characteristics, treatment details, and outcome were evaluated. Results Compared with the trans‐abdominal approach group, the local excision group patients had smaller size and lower location tumors ( P < 0.05). Positive resection margin was an important hazard factor for DFS (OR, 7.63; P = 0.015). Among the patients with the tumor size >5 cm, those with preoperative Imatinib therapy had higher rate of a negative resection margin than those without (100% vs. 20%, P = 0.048). Among the patients with intermediate and high‐risk tumors, those who received peri‐operative Imatinib therapy had longer DFS compared with those without (61.3 ± 6.1 months vs. 20.2 ± 4.4 months, P = 0.030). Conclusions The location of rectal GIST impacts the choice of resection type. Most patients with tumors within 5 cm of the anal verge can be treated with local excision. Positive resection margin is the independent hazard factor for poorer survival. Peri‐operative Imatinib therapy is associated with a prolonged DFS in patients with intermediate and high‐risk tumors. J. Surg. Oncol 2014; 109:708–713 . © 2014 Wiley Periodicals, Inc.