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Isolated limb perfusion with melphalan for melanoma
Author(s) -
Nieweg Omgo E.,
Kroon Bin B.R.
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23558
Subject(s) - melphalan , medicine , perfusion , limb perfusion , melanoma , surgery , radiology , chemotherapy , cancer research
Isolated limb perfusion with melphalan is a well‐established and effective treatment for inoperable melanoma metastases of the extremities, with an overall response rate of 80% and a complete response rate of 54%. The surgical technique is complex and serious morbidity can occur, but with attention to detail major side effects can be kept to a minimum. This article reviews the technique, results and other aspects of this sophisticated form of treatment. J. Surg. Oncol. 2014 109:332–337 . © 2014 Wiley Periodicals, Inc.