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Preoperative transarterial chemoembolization and resection for hepatocellular carcinoma: A nationwide Taiwan database analysis of long‐term outcome predictors
Author(s) -
Shi HonYi,
Wang ShenNien,
Wang Shih Chin,
Chuang ShihChang,
Chen ChunMin,
Lee KingTeh
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23521
Subject(s) - medicine , hepatocellular carcinoma , propensity score matching , cirrhosis , logistic regression , cohort , hepatectomy , resection , population , retrospective cohort study , database , surgery , environmental health , computer science
Background To explore long‐term predictors of outcome after TACE and resection in a population of patients with hepatocellular carcinoma (HCC). Methods A total of 648 had received TACE before liver resection (TACE group) while 10,431 patients had received liver resection without TACE (LR group). Propensity scores were calculated by entering the patient data into a logistic regression model for predicting HCC outcomes. Results Compared to the LR group, the TACE group did not significantly differ in disease‐free survival (DFS) (median, 17 months in the TACE group vs. 13 months in the LR group; P = 0.410) and overall‐survival (OS) (median, 56 months in the TACE group vs. 54 months in the LR group; P = 0.777). The TACE group also showed that gender, liver cirrhosis, CCI score, hospital volume, and surgeon volume were independently associated with DFS while gender, CCI score and hospital level were independently associated with DFS/OS. Conclusions This population‐based cohort study provides compelling evidence that preoperative TACE does not significantly reduce DFS or OS in patients with resectable HCC. Moreover, long‐term outcomes for these procedures are significantly associated with patient characteristics and hospital characteristics. Medical professionals and health care providers should carefully evaluate candidates for preoperative TACE in patients with resectable HCC. J. Surg. Oncol. 2014 109:487–493 . © 2013 Wiley Periodicals, Inc.