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Local recurrence after radical nephrectomy for kidney cancer: management and prediction of outcomes. a multi‐institutional study
Author(s) -
Paparel Philippe,
Bigot Pierre,
Matillon Xavier,
Bensalah Karim,
Salomon Laurent,
Baumert Hervé,
Bastide Cyril,
Thuret Rodolphe,
Karsenty Gilles,
Long Jean Alexandre,
Ammi Myriam,
Bessede Thomas,
Bin Sylvie,
Roux Adeline,
Escudier Bernard,
Rioux Leclercq Nathalie,
Pignot Géraldine,
Soulie Michel,
Patard JeanJacques
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23473
Subject(s) - medicine , nephrectomy , lymph node , kidney cancer , multivariate analysis , disease , surgery , cancer , retrospective cohort study , kidney , fossa , urology
Background Local recurrence (LR) after radical nephrectomy (RN) for kidney cancer is uncommon. Our objectives were to analyse characteristics and therapeutic options of LR after RN and to identify survival prognostic factors. Materials and Methods From a multi‐institutional retrospective database, we identified 72 patients who experienced LR after RN. Results Mean time to LR was 26.5 ± 3.3 months. The location of the recurrence was renal fossa, regional lymph node, homolateral adrenal and both renal fossa and regional lymph node for 43 (59.7%), 27 (37.5%), 9 (12.5%) and 7 (9.7%) patients, respectively. Patients were treated by surgery, systemic therapies, combination of therapies and palliative treatment in 24 (33.3%), 18 (25%), 24 (33.3%) and 6 (8.4%) cases, respectively. Within a mean follow‐up of 26.4 ± 3.3 months from the date of local recurrence, 12 (16.6%) patients were alive without disease, 30 (41.7%) patients were alive with disease, 30 patients (41.6%) died including 28 (38.8%) from the disease. In multivariate analysis, time to recurrence <1 year ( P < 0.001; HR: 4.81) and surgical treatment ( P = 0.027; HR: 0.33) were predictive factors. Conclusions Local recurrence after radical nephrectomy is associated with poor prognosis. The time to recurrence and the completeness of the surgical treatment are major prognostic factors. J. Surg. Oncol. 2014 109:126–131 . © 2013 Wiley Periodicals, Inc.