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A matched case‐control study of IBD‐associated colorectal cancer: IBD portends worse outcome
Author(s) -
Hrabe Jennifer E.,
Byrn John C.,
Button Anna M.,
Zamba Gideon K.,
Kapadia Muneera R.,
Mezhir James J.
Publication year - 2014
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23465
Subject(s) - medicine , colorectal cancer , multivariate analysis , gastroenterology , stage (stratigraphy) , univariate analysis , inflammatory bowel disease , cancer , disease , oncology , biology , paleontology
Background and Objectives The effect of inflammatory bowel disease (IBD) on outcome in patients with colorectal cancer (CRC) remains unclear. Our objective is to evaluate oncologic outcomes of patients with IBD‐associated CRC. Methods We retrospectively reviewed a prospectively maintained database to identify patients with IBD‐associated CRC. Clinicopathologic variables and overall survival were compared to patients with sporadic CRC using a 2:1 matched‐controlled analysis. Results Fifty‐five patients with IBD and CRC were identified. On univariate analysis, CRC patients with IBD had a significantly shorter median overall survival (68.2 months vs. 204.3 months, P = 0.01) compared to patients with sporadic CRC. On multivariate analysis, after adjusting for N and M stage, IBD was associated with an increased risk of death compared to sporadic CRC (HR = 2.011, 95% CI 1.24–3.23, P = 0.004). Stage 3 CRC patients with IBD in particular showed significantly decreased survival (23.0 vs. 133.9 months, P = 0.008). Conclusions In this study, patients with node‐positive IBD‐associated CRC had a significant increased risk of death and a shorter overall survival than those with sporadic disease and may require tailored adjuvant therapy and surveillance protocols. Continued investigation to elucidate the mechanisms that contribute to these observations is justified. J. Surg. Oncol. 2014 109:117–121 . © 2013 Wiley Periodicals, Inc.