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Prognostic value of total tumor volume in advanced‐stage laryngeal and hypopharyngeal carcinoma
Author(s) -
Yang ChanJoo,
Kim DaeYoon,
Lee Jeong Hyun,
Roh JongLyel,
Choi SeungHo,
Nam Soon Yuhl,
Kim Sang Yoon
Publication year - 2013
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23444
Subject(s) - medicine , hypopharyngeal cancer , larynx , stage (stratigraphy) , univariate analysis , multivariate analysis , t stage , carcinoma , oncology , gastroenterology , perineural invasion , cancer , surgery , paleontology , biology
Background To evaluate the prognostic value of total tumor volume (TTV) in patients with laryngeal and hypopharyngeal carcinomas. Methods This study involved 182 patients with previously untreated advanced‐stage squamous cell carcinoma of the larynx or hypopharynx. TTV were calculated from pretreatment contrast‐enhanced computed tomography images. Univariate and multivariate analyses were used to identify factors associated with overall (OS), disease‐specific (DSS), and disease‐free survival (DFS). Results At a median follow‐up of 63 months (range, 24–139 months), the 5 year OS, DSS, and DFS rates were 60.2%, 73.1%, and 69.4%, respectively. Multivariate analyses showed that tumor site was an independent predictor of DSS ( P = 0.03); Charlson comorbidity index for OS ( P = 0.001); second primary cancer for OS ( P = 0.008) and DFS ( P = 0.001); and vocal fold paralysis for DSS ( P = 0.014) and DFS ( P = 0.033). Extension to the tongue base was an independent predictor of OS ( P = 0.007), DSS ( P < 0.001), and DFS ( P = 0.017), and TTV ≥8.38 ml was an independent predictor of all three survivals ( P < 0.001 each). Conclusion Radiologically determined TTV is prognostic of survival in patients with advanced‐stage laryngeal and hypopharyngeal carcinoma. J. Surg. Oncol. 2013; 108:509–515 . © 2013 Wiley Periodicals, Inc.