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Excess of extracolonic non‐endometrial multiple primary cancers in MSH2 germline mutation carriers over MLH1
Author(s) -
LinHurtubise Kevin M.,
Yheulon Christopher G.,
Gagliano Ronald A.,
Lynch Henry T.
Publication year - 2013
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23413
Subject(s) - msh2 , mlh1 , medicine , endometrial cancer , lynch syndrome , cancer , oncology , germline mutation , colorectal cancer , gastroenterology , cancer research , dna mismatch repair , mutation , biology , genetics , gene
Abstract Background The lynch syndrome (LS) tumor spectrum involves colorectal cancer (CRC), endometrial cancer (EC), and less frequently various extracolonic non‐endometrial cancers (non‐EC). The organ‐specific survival rates of these patients are well defined, however, the collective survival of all‐cancers combined (CRC + EC + non‐EC) are unclear. Methods Fifty‐two MSH2 patients and 68 MLH1 patients were followed for a median of 6.3 years after diagnosis of first cancer, regardless of type. The proportions of CRC only, EC, non‐EC, and multiple primary cancers were compared between the two genotypes. Kaplan–Meier curves were developed for survival comparisons. Results MSH2 patients present less frequently with only CRC (37% MSH2, 62% MLH1, P = 0.0096), manifest more multiple primary cancers (38% MSH2, 18% MLH1, P = 0.013), develop more extracolonic cancers (62% MSH2, 38% MLH1, P = 0.003), non‐EC only cancers (46% MSH2, 24% MLH1, P = 0.028) and carry a greater risk for urinary tract cancer (UTC) (13.4% MSH2, 1.5% MLH1, P = 0.024). There was no difference in 10‐year survival between the two groups ( P = 0.4). Conclusion The additional propensity for UTC in MSH2 carriers argues in favor of UTC screening in MSH2 individuals. Other types of cancer screening should be tailored to the expression history of the specific LS mutation. J. Surg. Oncol. 2013; 108:433–437 . © 2013 Wiley Periodicals, Inc.