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Liver resection for metastatic melanoma: Equivalent survival for cutaneous and ocular primaries
Author(s) -
Ryu Seung Wook,
Saw Robyn,
Scolyer Richard A.,
Crawford Michael,
Thompson John F.,
Sandroussi Charbel
Publication year - 2013
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23361
Subject(s) - medicine , ocular melanoma , melanoma , resection , metastatic melanoma , dermatology , surgery , cancer research
Background The value of surgical resection in patients with hepatic metastases from melanoma is poorly documented in the literature. This study sought to determine the clinicopathologic and surgical factors predictive of outcome for melanoma patients who underwent resection of hepatic metastases. Methods Thirty‐three patients who underwent liver resection for melanoma metastases were identified from the Melanoma Institute Australia research database. Univariate and multivariate analyses were performed to identity factors predictive of recurrence and survival following liver resection for melanoma metastasis. Results The actuarial 2‐ and 5‐year survival rates were 59% and 42%, respectively, with a median survival of 29 months (range 1–139). The 5‐year survival rates for cutaneous and ocular primary melanoma were 44% and 39%, respectively. Improved post‐hepatic metastasectomy survival was observed in patients with microscopically clear resection margins (R0, 44 months; R1/2, 12 months; P = 0.04). Although major hepatic resection was associated with improved survival (major, 70 months; minor, 23 months; P = 0.07), major hepatectomies were performed almost exclusively in patients with isolated liver metastases. Conclusions Hepatic resection for metastatic melanoma is associated with improved survival in selected patients with both primary ocular and cutaneous melanoma. Surgical treatment of hepatic melanoma metastases should be considered when complete resection is feasible. J. Surg. Oncol. 2013; 108:129–135 . © 2013 Wiley Periodicals, Inc.