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Prognostic value of the D‐dimer test in oesophageal cancer during the perioperative period
Author(s) -
Diao Dongmei,
Zhu Kun,
Wang Zhe,
Cheng Yao,
Li Kang,
Pei Leilei,
Dang Chengxue
Publication year - 2013
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23339
Subject(s) - medicine , perioperative , d dimer , cancer , stage (stratigraphy) , gastroenterology , surgery , paleontology , biology
Background There has been little research on the perioperative D‐dimer levels in oesophageal cancer patients. Plasma D‐dimer levels can be used to predict the outcome in cancer patients. Methods A cancer group of 66 oesophageal cancer patients and a control group of 12 patients with benign disease were enrolled in this cohort study. The plasma D‐dimer levels during the pre‐operation and 3rd and 9th day post‐operation periods were prospectively examined and analysed between the two groups. Plasma D‐dimer levels were also compared with the clinicopathological characteristics and 3‐year survival of the oesophageal cancer patients. Results Plasma D‐dimer levels increased in both groups after surgery, but they were significantly higher in the cancer group. In oesophageal cancer patients, pre‐operation plasma D‐dimer levels were significantly higher in TNM stage IV patients. Perioperative plasma D‐dimer levels significantly increased after surgery, and the survival was shortened in those patients whose D‐dimer levels on the 3rd and 9th post‐operative day above the median. In addition, increased plasma D‐dimer levels at the 3rd and 9th days after surgery were influenced by the patient's age. Conclusion In oesophageal cancer patients, D‐dimer levels increased after surgery, and the increases were associated with poor outcomes. J. Surg. Oncol. 2013 108:34–41 . © 2013 Wiley Periodicals, Inc.