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Clinical outcomes for rectal carcinoid tumors according to a new (AJCC 7th edition) TNM staging system: A single institutional analysis of 122 patients
Author(s) -
Kim Min Sung,
Hur Hyuk,
Min Byung Soh,
Baik Seung Hyuk,
Lee Kang Young,
Kim Nam Kyu
Publication year - 2013
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23327
Subject(s) - medicine , stage (stratigraphy) , colorectal cancer , distant metastasis , lymph node , t stage , oncology , neuroendocrine tumors , overall survival , metastasis , gastroenterology , tnm staging system , survival rate , cancer , neoplasm staging , paleontology , biology
Background and Objectives This study aimed to describe clinical outcomes of rectal carcinoids according to the 7th American Joint Council on Cancer (AJCC) TNM staging system. Methods We retrospectively reviewed 122 patients who were treated for rectal carcinoids between 1995 and 2010. Results Among 122 patients, 81.2% (n = 99) were classified as stage I, 4.9% (n = 6) as stage II, 11.5% (n = 14) as stage III, and 2.5% (n = 3) as stage IV. Lymph node (LN) metastasis rates for pT1a, 1b, 2, and 3 stages were 1.2% (1/85), 16.7% (3/18), 0% (0/4) and 84.6% (11/13), respectively. The 5‐year overall survival (OS) rate was 88.4%. The 5‐year OS rates were estimated to be 100%, 80%, 51.4% and 0% for stage I, II, III, and IV, respectively ( P < 0.001). The 5‐year disease‐free survival (DFS) rate was 82.3%. The 5‐year DFS rates were estimated to be 97.7%, 62.5%, 17.1%, and 0% for stages I, II, III, and IV, respectively ( P < 0.001). Conclusions Using the new TNM stage, we confirmed a prognostic difference in LN metastasis rates, OS, and DFS for rectal carcinoids. In clinical practice, the new TNM stage can be very useful for predicting prognosis. J. Surg. Oncol. 2013;107:835–841. © 2013 Wiley Periodicals, Inc.