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Genomic Dysregulation in gastric tumors
Author(s) -
Janjigian Yelena Y.,
Kelsen David P.
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23263
Subject(s) - cancer , medicine , epigenetics , disease , histopathology , pathology , gene , cancer research , oncology , biology , genetics
Abstract Gastric cancer is among the most common human malignancies and the second leading cause of cancer‐related death. The different epidemiologic and histopathology of subtypes of gastric cancer are associated with different genomic patterns. Data suggests that gene expression patterns of proximal, distal gastric cancers‐intestinal type, and diffuse/signet cell are well separated. This review summarizes the genetic and epigenetic changes thought to drive gastric cancer and the emerging paradigm of gastric cancer as three unique disease subtypes. J. Surg. Oncol. 2013;107:237–242. © 2012 Wiley Periodicals, Inc.