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18 F‐fluorodeoxyglucose uptake predicts pathological complete response after neoadjuvant chemotherapy for breast cancer: A retrospective cohort study
Author(s) -
Jin Soyoung,
Kim SungBae,
Ahn JinHee,
Jung Kyung Hae,
Ahn Sei Hyun,
Son Byung Ho,
Lee Jong Won,
Gong Gyungyub,
Kim Hye Ok,
Moon Dae Hyuk
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23255
Subject(s) - medicine , breast cancer , chemotherapy , univariate analysis , confidence interval , neoadjuvant therapy , standardized uptake value , odds ratio , multivariate analysis , pathological , retrospective cohort study , oncology , cancer , fluorodeoxyglucose , complete response , gastroenterology , positron emission tomography , nuclear medicine
Background and Objectives 18 F‐fluorodeoxyglucose ( 18 F‐FDG) uptake may identify poorly differentiated tumors with a high proliferation rate that are more responsive to neoadjuvant chemotherapy. Methods We retrospectively evaluated 273 patients (mean age, 44.2 years; range 23–78 years) newly diagnosed with stage II or III invasive ductal breast cancer between 2006 and 2010. All patients were treated with neoadjuvant chemotherapy followed by surgery. The ability of parameters to predict pathological complete response (pCR), was assessed by multivariate analysis. Results Of the 273 breast cancer patients, 30 (11.0%) achieved pCR. Univariate analysis revealed that higher histologic grade ( P < 0.001), lack of estrogen receptor (ER, P < 0.001); and a higher maximal standardized uptake value (SUVmax, P < 0.001) were associated with pCR, whereas HER2/neu amplification and Ki‐67 expression were not ( P > 0.05 for each comparison). Multivariate analysis showed that negative ER (odds ratio [OR] = 9.98; 95% confidence interval [CI], 2.88–34.52, P < 0.001) and the SUVmax of 18 F‐FDG uptake (OR per one unit increase in SUVmax = 1.09; 95% CI, 1.02–1.16, P = 0.008) were independent predictors of pCR. Conclusions ER status and 18 F‐FDG uptake are independent predictors of pCR after neoadjuvant chemotherapy for breast cancer. J. Surg. Oncol. 2013;107:180–187. © 2012 Wiley Periodicals, Inc.