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Molecular pathways in pancreatic carcinogenesis
Author(s) -
MacgregorDas Anne M.,
IacobuzioDonahue Christine A.
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23213
Subject(s) - pancreatic intraepithelial neoplasia , pancreatic cancer , medicine , intraductal papillary mucinous neoplasm , carcinogenesis , pancreas , pancreatic disease , pathology , disease , cancer research , cancer , pancreatic ductal adenocarcinoma , oncology
Abstract Pancreatic cancer is a genetic disease. Pancreatic cancers develop from one of three precursor lesions, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs), and each arises in association with distinct genetic alterations. These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors. J. Surg. Oncol. 2013;107:8–14. © 2012 Wiley Periodicals, Inc.