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Cushing's syndrome
Author(s) -
Hatipoglu Betul A.
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23197
Subject(s) - medicine , dexamethasone suppression test , dexamethasone , cushing syndrome , endocrinology , adrenal adenoma , urinary system , endogeny , hydrocortisone , adrenocortical adenoma , adenoma
Cushing's syndrome (CS) results from prolonged exposure to elevated endogenous cortisol. Majority of cases are caused by ACTH, pituitary, or ectopic origin. Primary adrenal hypersecretion is 15–20% caused by adenomas, carcinomas (ACC), and rarely by nodular adrenocortical disease. CS presents with all typical features. Commonly recommended initial testing are urinary free cortisol, late‐night salivary cortisol, and 1‐mg overnight dexamethasone suppression test (DST). Imaging is the key to diagnosis. CS continues to pose diagnostic and therapeutic challenges; life‐long follow‐up is mandatory. J. Surg. Oncol. 2012; 106:565–571. © 2012 Wiley Periodicals, Inc.