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Solid‐pseudopapillary tumor of the pancreas: Clinical features, pathological characteristics, and origin
Author(s) -
Ye Jinhua,
Ma Mingzhe,
Cheng Dongfeng,
Yuan Fei,
Deng Xiaxing,
Zhan Qian,
Shen Baiyong,
Peng Chenghong
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23195
Subject(s) - pathological , pancreas , pathology , medicine , capsule , clear cell , electron microscope , cytoplasm , biology , carcinoma , microbiology and biotechnology , botany , physics , optics
Objectve To study clinically pathological features and origin of solid‐pseudopapillary tumor of pancreas (SPT). Patients and Methods Clinical and pathological data of 82 cases with SPT were retrospectively studied. SAS6.12 statistics package was used for analysis. P < 0.05 was regarded as statistically significant difference. Results The SPT patients included 70 females and 12 males, with a median age of 31 years old. The mean tumor size was 6.71 ± 4.42 cm. Vascular or organs was invaded in nine cases. The clinical and pathological characteristics show no significant difference between male and female patients. In the non‐encapsulate group (22 cases), the tumor was larger ( P = 0.0015), exogenous growth pattern ( P = 0.0194), and would probably involve major vascular or organs ( P = 1.697E−06). The typical features of SPT include pseudopapillary pattern with fibro vascular stalks by uniform poorly cohesive polygonal cells. The tumor cell expresses a variety of immune markers in heterogeneity. Under electron microscope, there are some electron dense granules, about 8–1.2 µm in diameter, with membrane similar to the zymogen granules in SPT cell cytoplasm. Conclusions SPT with incomplete capsule often presents malignant behaviors. SPT shows multi‐heterogeneity, which is caused by the disorder in the development of pancreatic stem cell. J. Surg. Oncol. 2012; 106:728–735. © 2012 Wiley Periodicals, Inc.