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The correlations between the expression of FGFR4 protein and clinicopathological parameters as well as prognosis of gastric cancer patients
Author(s) -
Ye YanWei,
Zhang Xiefu,
Zhou Ye,
Wu Jianghong,
Zhao Chunlin,
Yuan Lin,
Wang Guojun,
Du Chunyan,
Wang Chunmeng,
Shi Yingqiang
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23153
Subject(s) - medicine , fibroblast growth factor receptor 4 , immunohistochemistry , stage (stratigraphy) , oncology , cancer , protein expression , survival analysis , multivariate analysis , subgroup analysis , stomach , proliferating cell nuclear antigen , overall survival , gastroenterology , pathology , receptor , fibroblast growth factor , fibroblast growth factor receptor , biology , gene , confidence interval , genetics , paleontology
Background Fibroblast growth factor receptor 4 (FGFR4) was seldom investigated in gastric cancer (GC). The purpose of the study was to elucidate the expression of FGFR4 protein in GC and related clinical significance. Methods Ninety‐four paraffin‐embedded tumor specimens were obtained from Cancer Hospital, Fudan University. The expression of FGFR4 as well as p53, p21, EGFR, neu, c‐myc, and PCNA were detected by immunohistochemical method. Then, correlation analysis and survival analysis were performed. Results The expression rate of FGFR4 protein in GC tissues and normal stomach tissues was 93.6% and 30.8%, respectively ( P = 0.000). The expression of FGFR4 was positively correlated with the expression of p21, neu and PCNA ( P ‐value was 0.009, 0.012, and 0.018, respectively). Subgroup analysis showed that compared to low expression group, the prognosis of patients with III/IV stage and negative expression of p21 in high expression group of FGFR4 were worse ( P = 0.048, 0.041, respectively). Multivariate analysis showed that TNM stage was the independent prognostic factor in high expression group (HR, 11.593; 95% CI, 3.532–18.058; P = 0.000). Conclusions High expression of FGFR4 protein, accelerating the progression of advanced GC, might be associated with a poor prognosis in patients with advanced FC. J. Surg. Oncol. 2012; 106:872–879. © 2012 Wiley Periodicals, Inc.