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Impact of esophageal invasion on clinicopathological characteristics and long‐term outcome of adenocarcinoma of the subcardia
Author(s) -
Tokunaga Masanori,
Tanizawa Yutaka,
Bando Etsuro,
Kawamura Taiichi,
Tsubosa Yasuhiro,
Terashima Masanori
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23152
Subject(s) - medicine , gastroenterology , esophageal adenocarcinoma , esophagectomy , adenocarcinoma , esophageal cancer , esophagus , stage (stratigraphy) , hazard ratio , pathological , survival rate , esophageal disease , oncology , cancer , confidence interval , paleontology , biology
Abstract Backgrounds and Objectives A different classification system was used in the 7th edition of the TNM classification for adenocarcinoma of the subcardia either with or without esophageal invasion. The aim of this study was to clarify the clinicopathological and survival impact of esophageal invasion. Methods The present study included 351 patients who underwent gastrectomy for adenocarcinoma located within 5 cm of the esophagogastric junction. The clinicopathological characteristics and survival curves were compared between patients with esophageal invasion [E (+) group, n = 125] and without esophageal invasion [E (−) group, n = 226]. Results Patients in the E (+) group had more advanced disease. The 5‐year survival rate following macroscopic curative resection was significantly better in the E (−) group (80.8%) than in the E (+) (48.7%, P < 0.001), even after stratification by the pathological stage and nodal status. Multivariate analysis identified esophageal invasion (hazard ratio; 3.323, 95% confidential interval; 1.815–6.082) as one of the independent prognostic factors. Conclusions Esophageal invasion affected the clinicopathological characteristics and long‐term outcome of patients. Further study is necessary to clarify whether patients with esophageal invasion should be classified using the system for esophageal cancer or by another method. J. Surg. Oncol. 2012; 106:856–861. © 2012 Wiley Periodicals, Inc.