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Patient rated outcomes and survivorship following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS + HIPEC)
Author(s) -
Duckworth Katharine E.,
McQuellon Richard P.,
Russell Gregory B.,
Cashwell Craig S.,
Shen Perry,
Stewart John H.,
Levine Edward A.
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23089
Subject(s) - medicine , survivorship curve , hyperthermic intraperitoneal chemotherapy , quality of life (healthcare) , psychosocial , cytoreductive surgery , population , frailty index , psychological intervention , physical therapy , chemotherapy , cancer , surgery , psychiatry , ovarian cancer , nursing , environmental health
Background Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS + HIPEC) is a treatment combining cytoreductive surgery with hyperthermic chemotherapy directly into the peritoneal cavity. Recipients may gain extended life when compared with best supportive care; yet results often are achieved with substantial morbidity and health‐related quality of life (HRQOL) deficits. The purpose of this study was to record patient rated outcomes and the HRQOL of long‐term survivors. Methods One hundred and two patients living 12+ months post‐treatment completed a survey including the Medical Outcomes Study 36‐item Short Form Health Survey (SF‐36), Functional Assessment of Cancer Therapy‐Colon (FACT‐C), and Pittsburgh Sleep Quality Index. Results SF‐36 Physical Component scores were significantly lower than general population norms (46.7, z = −2.943, P = 0.003), while Mental Component scores were significantly higher (53.6, z = 4.208, P ≤ 0.001). FACT scores were higher than general FACT normative scores. The majority (56%) of these survivors reported significant sleep quality impairment. Conclusion Although most HRQOL scores were comparable to or higher than those of the general population, long‐term physical and functional deficits remain. These deficits, along with the poor sleep quality of recipients, may be improved by survivorship programs or targeted psychosocial interventions. J. Surg. Oncol. 2012; 106:376–380. © 2012 Wiley Periodicals, Inc.