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Tumor spectrum in lynch syndrome, DNA mismatch repair system and endogenous carcinogens
Author(s) -
MedinaArana Vicente,
Delgado Luciano,
Bravo Alberto,
Martín Juana,
FernándezPeralta Antonia M.,
GonzálezAguilera Juan J.
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23054
Subject(s) - dna mismatch repair , endogeny , medicine , dna repair , carcinogen , cancer research , broad spectrum , lynch syndrome , dna , mutation , gene , genetics , biology , chemistry , combinatorial chemistry
Inactivation of Mismatch Repair genes in Lynch Syndrome, caused by inherited mutations, decreases the ability to repair DNA errors throughout life. This deficit may allow the development of any tumor type. Nevertheless, the Syndrome develops a specific tumor spectrum associated with the disease. We think that such spectrum of tumors would be related to the action of certain endogenous carcinogens such as bile acids and estrogens that aggravate the inherited defect. J. Surg. Oncol. 2012; 106:10–16. © 2012 Wiley Periodicals, Inc.