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A new heart: Somatic stem cells and myocardial regeneration
Author(s) -
Mullenix Philip S.,
Huddleston Steven J.,
Stojadinovic Alexander,
Trachiotis Gregory D.,
Alexander Edmund P.
Publication year - 2012
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23014
Subject(s) - medicine , stem cell , regeneration (biology) , somatic cell , intensive care medicine , heart failure , cardiology , microbiology and biotechnology , biology , biochemistry , gene
End‐stage heart failure is a global scourge. Current therapies merely delay its inexorable progression. Heart transplantation is resource‐intensive and limited by organ availability. Bone marrow‐derived and cardiac‐specific stem cells have demonstrated potential for cardiac regeneration and repair, but the magnitude and durability of these promising findings are inconsistent. The purpose of this review is to (1) describe cells currently being investigated, (2) outline the status of current trials, and (3) discuss key objectives of future research. J. Surg. Oncol. 2012; 105:475–480. © 2012 Wiley Periodicals, Inc.