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Elevated high‐sensitivity C‐reactive protein, a marker of advanced stage gastric cancer and postgastrectomy disease recurrence
Author(s) -
Woo Yanghee,
Hyung Woo Jin,
Obama Kazutaka,
Kim HyoungIl,
Pak Kyung Ho,
Son Taeil,
Noh Sung Hoon
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.22129
Subject(s) - medicine , gastroenterology , cancer , stage (stratigraphy) , gastrectomy , c reactive protein , tumor marker , surgery , oncology , inflammation , paleontology , biology
Background and Objectives Gastric cancer recurrence after curative surgery remains high. Although no preoperative marker of gastric cancer progression after radical gastrectomy exists, recent studies suggest that C‐reactive protein (CRP) is associated with cancer progression. Our study evaluated the significance of preoperative high‐sensitivity CRP (hs‐CRP) levels as a marker of disease progression after radical gastrectomy. Methods The preoperative hs‐CRP levels of 1,221 gastric cancer patients who underwent radical gastrectomies were analyzed for clinicopathologic significance. Patients with previous gastric cancer treatment, another primary cancer, active infection, or postoperative mortality were excluded. Results hs‐CRP levels were significantly associated with increased tumor depth ( P = 0.028), nodal status ( P = 0.012), and stage ( P = 0.045). Seventeen percent of patients had elevated hs‐CRP levels at the cutoff value of >3.00 mg/L, whereas 6.6% and 6.1% of patients had CEA and CA‐19‐9 levels about the cutoffs of ≥5.00 ng/ml and ≥35.0 U/L, respectively. Hs‐CRP levels >3.00 mg/L were an independent risk factor for recurrence‐free survival along with stage. Conclusion Elevated preoperative hs‐CRP levels in gastric cancer patients are clinically significant indicators of advanced stage and postoperative disease recurrence. J. Surg. Oncol. 2012;105:405–409. © 2011 Wiley Periodicals, Inc.