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High phosphorylated 4E‐binding protein 1 expression after chemoradiotherapy is a predictor for locoregional recurrence and worse survival in esophageal squamous cell carcinoma patients
Author(s) -
Chao YinKai,
Chuang WenYu,
Yeh ChiJu,
Chang YuSun,
Wu YiCheng,
Kuo ShaoYun,
Hsieh MingJu,
Hsueh Chuen
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.22097
Subject(s) - medicine , immunohistochemistry , esophageal cancer , oncology , chemoradiotherapy , proportional hazards model , pathological , carcinoma , survival rate , survival analysis , cancer , pathology
Background As a well‐known pivotal factor of 4E‐binding protein 1 (4E‐BP1) in controlling cancer proliferation, high expression of its phosphorylated form (p‐4E‐BP1) has been reported to be associated with poor outcome in various human cancers without pretreated with chemoradiotherapy (CRT). However, no data is available regarding the implication of p‐4E‐BP1 expression after CRT. Therefore, we conducted this study. Methods The expression of p‐4E‐BP1 was semiquantitatively examined with immunohistochemical staining in 60 ypT1T2 esophageal squamous cell carcinoma (SCC) patients and verified by western blot analysis in representative cases. The impact of p‐4E‐BP1 expression intensity on cancer recurrence and survival was assessed in combination with clinical and pathological descriptors. Result The 5‐year disease specific survival (DSS) rate of patients with high p‐4E‐BP1 expression was significantly lower than that of patients with lower p‐4E‐BP1 expression (5 year DSS: 58% vs. 8.6%, P = 0.00064). Furthermore, in a multivariate analysis by Cox regression model, high p‐4E‐BP1 expression was confirmed to be an independent prognostic factor (HR: 2.269; unfavorable, P = 0.024) for DSS, while lymph node (HR: 3.016; unfavorable, P = 0.005) was also significant prognostic factor. High p‐4E‐BP1 expression was specifically associated with locoregional recurrence (LR; P < 0.05). The locoregional control rate reached 97.1% in low p‐4E‐BP1 tumors. Conclusion High p‐4E‐BP1 expression after CRT is a predictor for LR and worse survival in esophageal SCC patients. J. Surg. Oncol. 2012; 105:288–292. © 2011 Wiley Periodicals, Inc.