Premium
Does neoadjuvant chemotherapy reveal disease precluding surgical treatment of initially resectable colorectal cancer liver metastases?
Author(s) -
Reddy Srinevas K.,
Tsung Allan,
Marsh James Wallis,
Geller David A.
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.22044
Subject(s) - medicine , chemotherapy , occult , colorectal cancer , neoadjuvant therapy , surgery , cancer , oncology , gastroenterology , pathology , breast cancer , alternative medicine
Background The objective of this study is to determine whether neoadjuvant chemotherapy reveals occult disease precluding surgical extirpation of initially resectable colorectal cancer liver metastases (CRCLM). Methods Demographics, clinicopathologic tumor characteristics, treatments, and post‐operative outcomes of patients aged 18–80 years, with one to four initially resectable CRCLM, and without concurrent extra‐hepatic (EHMD) or previous metastatic disease were reviewed. Results Two hundred and two patients evaluated from 2000 to 2010 met study criteria; 88 (43.6%) were given neoadjuvant chemotherapy. Patients treated with neoadjuvant chemotherapy were younger (median 58 years vs. 65 years, P = 0.0096), had shorter disease free interval from resection of primary tumor to CRCLM diagnosis (median 0 months vs. 12 months, P < 0.0001), and had more CRCLM (median 1 [1–3] vs. 1 [1–2], P = 0.0096) compared to untreated counterparts. There were no differences in rates of concurrent EHMD noted intra‐operatively and not on pre‐operative imaging (4.5% vs. 3.5%, P = 0.7290), greater intra‐operatively observed CRCLM compared to pre‐operative imaging (25.3% vs. 17.5%, P = 0.2449), hepatic resection and/or ablation (97.7% vs. 100.0%, P = 0.9853), or 6‐month disease recurrence after surgical treatment (25.6% vs. 14.9%, P = 0.0882). Only two (2.3%) patients treated with neoadjuvant chemotherapy had disease progression precluding surgical extirpation. Conclusions Neoadjuvant chemotherapy for initially resectable CRCLM does not reveal occult disease precluding surgical treatment. J. Surg. Oncol. 2012; 105:55–59. © 2011 Wiley Periodicals, Inc.