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Systemic treatment of metastatic melanoma: New approaches
Author(s) -
Hamid Omid,
Boasberg Peter D.,
Rosenthal Katherine,
O'Day Steven J.
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.22034
Subject(s) - medicine , metastatic melanoma , melanoma , immunotherapy , targeted therapy , clinical practice , cancer research , cancer , family medicine
The field of melanoma therapeutics has experienced a dramatic paradigm shift over the last 12 months through recent discoveries of novel therapeutics targeting known oncogenes and immunotherapeutic antibodies. In this article, we review these findings and provide a framework to understand these discoveries, their significance in melanoma therapy, and role in clinical care. As this understanding grows, enduring therapeutic success may be achieved through tailored use of molecular markers and immunotherapies in sequential or combinatorial methods. J. Surg. Oncol. 2011; 104:425–429. © 2011 Wiley‐Liss, Inc.