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Peritoneal carcinomatosis of colon cancer origin: Highest incidence in women and in patients with right‐sided tumors
Author(s) -
Sjo Ole Helmer,
Berg Marianne,
Merok Marianne Arstad,
Kolberg Matthias,
Svindland Aud,
Lothe Ragnhild A.,
Nesbakken Arild
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21959
Subject(s) - medicine , incidence (geometry) , colorectal cancer , prospective cohort study , peritoneal carcinomatosis , gastroenterology , cancer , cohort , oncology , optics , physics
Background and Objectives : The aim of the study was to evaluate the incidence of peritoneal carcinomatosis (PC) in a prospectively recorded series of colon cancer patients from a defined cohort and to compare clinicopathological characteristics, survival, and TP53 mutation status in primary tumors from patients with and without PC. Methods : Clinical data from all colon cancer patients admitted in 1993–2006 were registered prospectively (n = 1,124). In a subset of PC patients, DNA was retrieved from tumor tissue and TP53 mutations analyzed and compared to the mutation status in a historical series. Results : In the prospective series 10% of female and 7% of male patients had PC ( P = 0.05). The PC patients were younger than those without PC (median 4 years, P = 0.002). The incidence of PC was 10.3% and 6.2% ( P = 0.03) in patients with primary tumors in the right and left colon, respectively. TP53 was mutated in 57% of the PC patients as compared to 41% in the series of patients without PC ( P = 0.05). Conclusions : The incidence of PC was higher in right‐sided colon cancer and among women. PC patients were younger than non‐PC patients, and PC was independently associated with TP53 mutation in the primary tumor. J. Surg. Oncol. © 2011 Wiley Periodicals, Inc.