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Prognostic impact of dihydropyrimidine dehydrogenase expression on pancreatic adenocarcinoma patients treated with S‐1‐based adjuvant chemotherapy after surgical resection
Author(s) -
Kondo Naru,
Murakami Yoshiaki,
Uemura Kenichiro,
Sudo Takeshi,
Hashimoto Yasushi,
Nakashima Akira,
Ohge Hiroki,
Sueda Taijiro
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21955
Subject(s) - dihydropyrimidine dehydrogenase , medicine , thymidylate synthase , chemotherapy , oncology , adenocarcinoma , immunohistochemistry , cancer research , fluorouracil , cancer
Background and Objectives The aim of this study is to investigate the prognostic value of intratumoral expression of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in patients treated with S‐1‐based chemotherapy after surgical resection for pancreatic adenocarcinoma. Methods Intratumoral TS, DPD, and OPRT expression was investigated in 106 patients with resected pancreatic adenocarcinoma by immunohistochemistry. Associations between clinicopathological factors, including intratumoral TS, DPD, and OPRT expression, and survival were evaluated by univariate and multivariate analyses. Results Of 106 patients, 72 had received S‐1‐based adjuvant chemotherapy (S‐1(+) group), and 34 had not (S‐1(−) group). High TS, DPD, and OPRT expression was observed in 64%, 37%, and 66% of patients, respectively. Among S‐1(+) group patients, survival was significantly better for patients with low DPD expression than for patients with high DPD expression ( P = 0.022). Intratumoral DPD expression was the only independent prognostic factor for patients treated with S‐1‐based adjuvant chemotherapy by multivariate analysis ( P = 0.037). Intratumoral TS and OPRT expression did not appear to influence survival. Conclusions Intratumoral DPD expression may be a relevant predictive marker of survival benefit associated with S‐1‐based adjuvant chemotherapy for pancreatic adenocarcinoma. J. Surg. Oncol. 2011;104:146–154. © 2011 Wiley‐Liss, Inc.