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The clinical use of indocyanine green as a near‐infrared fluorescent contrast agent for image‐guided oncologic surgery
Author(s) -
Schaafsma Boudewijn E.,
Mieog J. Sven D.,
Hutteman Merlijn,
van der Vorst Joost R.,
Kuppen Peter J.K.,
Löwik Clemens W.G.M.,
Frangioni John V.,
van de Velde Cornelis J.H.,
Vahrmeijer Alexander L.
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21943
Subject(s) - indocyanine green , medicine , cancer surgery , fluorescence lifetime imaging microscopy , surgery , radiology , reconstructive surgery , sentinel lymph node , fluorescence , cancer , physics , breast cancer , quantum mechanics
Optical imaging using near‐infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer‐related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non‐targeted and non‐conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence‐guided surgery. J. Surg. Oncol. 2011; 104:323–332. © 2011 Wiley‐Liss, Inc.