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Mass‐forming intrahepatic cholangiocarcinoma with marked enhancement on arterial‐phase computed tomography reflects favorable surgical outcomes
Author(s) -
Ariizumi ShunIchi,
Kotera Yoshihito,
Takahashi Yutaka,
Katagiri Satoshi,
Chen IPei,
Ota Takehiro,
Yamamoto Masakazu
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21917
Subject(s) - medicine , intrahepatic cholangiocarcinoma , hepatectomy , metastasis , radiology , computed tomography , nuclear medicine , cancer , gastroenterology , surgery , resection
Background Outcomes after hepatectomy in patients with mass‐forming (MF) type intrahepatic cholangiocarcinoma (ICC) with marked enhancement within the tumor on arterial‐phase computed tomography (CT) scans have not been clarified in detail. Methods We retrospectively studied 140 patients with MF type ICC who underwent hepatectomy from 1989 through 2008. Surgical outcomes were compared between 25 patients with MF type ICC with marked enhancement within the tumor (hypervascular ICC) and 109 patients without enhancement within the tumor (hypovascular ICC) on arterial‐phase CT scans. Results Portal invasion and intrahepatic metastasis were significantly lower in patients with hypervascular ICC than in those with hypovascular ICC. The 5‐year survival rate was significantly higher in patients with hypervascular ICC (86%) than in patients with hypovascular ICC (27%, P < 0.0001). Multivariate analysis showed hypervascular ICC on arterial‐phase CT scans, normal level of cancer‐associated carbohydrate antigen 19‐9, absence of portal invasion, and absence of intrahepatic metastasis of ICC to be significant independent prognostic factors for overall survival in patients with MF type ICC. Conclusions MF type ICC with marked enhancement within the tumor on arterial CT scans showed a favorable surgical outcome due to its less invasive histopathologic characteristics in patients with MF type ICC. J. Surg. Oncol. 2011;104:130–139. © 2011 Wiley‐Liss, Inc.