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Clinicopathologic factors associated with lymph node retrieval in resectable colon cancer: A veterans' affairs central cancer registry (VACCR) database analysis
Author(s) -
Gonsalves Wilson I,
Kanuri Swapna,
Tashi Tsewang,
Aldoss Ibrahim,
Sama Ashwin,
AlHowaidi Islam,
Ganta Ashwin,
Kalaiah Mudappa,
Thota Ramya,
Krishnamurthy Jairam,
Fang Xiang,
Townley Peter,
Ganti Apar K.,
Subbiah Shanmuga,
Silberstein Peter T.
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21886
Subject(s) - medicine , lymph , lymph node , colorectal cancer , logistic regression , stage (stratigraphy) , cancer , multivariate analysis , cancer registry , veterans affairs , retrospective cohort study , oncology , database , surgery , pathology , computer science , biology , paleontology
Background A long‐term determinant of survival in resectable colon cancer is the involvement of regional lymph nodes. We evaluated the clinicopathologic factors associated with lymph node retrieval. Methods We conducted a retrospective analysis of patients with resected stage I–III colon cancer in the Veteran's Affairs Central Cancer Registry between 1995 and 2008. One‐way ANOVA compared the differences between various groups. Multivariate logistic regression analysis was performed to determine the factors associated with the harvest of 12 or more lymph nodes for pathologic examination. Results There were 19,240 patients with resectable colon cancer included in our analysis. Mean number of lymph nodes retrieved increased with later year of diagnosis, higher overall stage, higher T descriptor, age <65 years, poorer differentiation and right‐sided tumors ( P < 0.01 for all covariates). These aforementioned factors are also associated with an increased probability of retrieving 12 or more lymph nodes after surgical resection ( P < 0.01 for all covariates). Conclusions Later year of diagnosis, younger patients, right‐sided tumors, poorer differentiation, higher T descriptor and overall stage are associated with increased number of lymph nodes retrieved. These may indicate the presence of an immunological response of tumor versus host affecting lymph node retrieval. J. Surg. Oncol. 2011; 104:667–671. © 2011 Wiley Periodicals, Inc.