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Clinically relevant information from sentinel lymph node biopsies of melanoma patients
Author(s) -
Wen DuanRen,
Cochran Alistair J.,
Huang RongRong,
Itakura Eijun,
Binder Scott
Publication year - 2011
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.21818
Subject(s) - medicine , sentinel node , melanoma , immunohistochemistry , sentinel lymph node , biopsy , lymph , pathology , oncology , radiology , dermatology , cancer , cancer research , breast cancer
Abstract Careful laboratory evaluation of sentinel nodes (SNs) is critical to determine the presence of tumor. This requires evaluation of multiple full‐face sections from the SN, using H&E staining and immunohistochemistry. In the future, molecular and genetic approaches may be adjunctive to microscopy. Number of tumor‐positive SNs and the amount and location of tumor in SNs correlate with tumor spread to non‐sentinel nodes, subsequent recurrences and melanoma death, permitting patient assignment to a risk category. J. Surg. Oncol. 2011; 104:369–378. © 2011 Wiley‐Liss, Inc.